England is starting with Manu Tuilagi at 12 on Saturday v Ireland, with Farrell at 10, Daly at full back, Lawes in second row and both Vunipola boys returning.
Ireland select Robbie Henshaw at full back, with Aki and Ringrose in centres, Toner in second row and Josh van der Flier on open side flank.
Scotland pick Sam Johnson at 12 for his debut against Italy, with James Ritchie replacing Hamish Watson in back row and Gary Graham on bench, set for his debut.
Wales have replaced injured Gareth Davies at scrum half with debutant, Tomas Williams, for opener against France, with Josh Navidi in back row and Liam Williams at 15.
France blood a couple of Toulouse youngsters out wide in Ntamack and Penaud, and include another new boy, South African born, Paul Willemse, in a monster pack, set to be the biggest ever in Six Nations.
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